A Comparison of Killed and Modified-Live Vaccines
The 2 most commonly used feline vaccines are killed and modified-live vaccines. Killed vaccines are incapable of producing disease and cannot replicate themselves within a vaccinated animal. Modified-live vaccines cannot, for the most part, include clinical disease, but they can replicate themselves within a vaccinated animal. The choice between killed and modified-live vaccines is influenced by circumstances. A veterinarian confident of obtaining effective immunity by using killed vaccine because it does not contain live virus.
Modified-live vaccines are chosen when a faster, more broad-based immune system response is desired because modified-live viruses continue to replicate in the vaccinated animal. They inspire the animal’s immune system to respond more rapidly with greater vigor than it would to be a killed-vaccine injection. Indeed, modified-live vaccines confer long-lasting protection from a single dose. Modified-live vaccines are also the only kind of vaccine that can be administered intranasally. This becomes a consideration when it is necessary to vaccinate against specific viruses that enter the body through nasal passages e.g. the upper respiratory viruses. Intranasal inoculations produce a special type of local immune response on the linings of the nasal passages. This response – which can be important in blocking the early phase of infection at the source – may not be as readily produced from systemic vaccination paths.
For every plus there is often a minus, and vaccines are no exception. Killed vaccines do not provoke as broad a range of response as modified-live vaccines do and there is a slightly greater chance that the preparation of killed vaccines will produce extraneous material in the vaccine – which could cause an adverse reaction. But this is not as much a problem today as it once was. Moreover, killed vaccines do not confer adequate protection in 1 dose. Consequently, a second or third injection should be administered at 4-weeks intervals following the initial vaccination.
For their part, modified-live vaccines have the exceedingly slight potential of reverting to a virulent form capable of producing disease instead of preventing it. (Reversion to virulence occurs infrequently and is incriminated more often that it should be). In addition, modified-live vaccines are less stable than other forms and may be able to infect a developing fetus if administered to a pregnant cat. (Modified-live vaccines are also dangerous for cats with corneal ulcers).
Queens should be vaccinated before breeding or at least at midterm of their pregnancy (with killed vaccines only) because queens cannot pass on antibodies through their milk to nursing kittens if they (the queens) do not possess those antibodies. Kittens should be vaccinated for the first time when they are 6 – 8 weeks old. After they have received their kitten vaccination(s), they should receive booster shots annually. Cats being shown regularly should be vaccinated every 6 months.
























